热卖商品
新闻详情
Abbiotec/GTP-CH-1 Antibody/250680/0.1 mg
来自 :
发布时间：2025-01-22
GTP cyclohydrolase 1 (GTP-CH-1 or GCH-1) catalyzes the conversion of GTP to D-erythro-7,8-dihydroneopterin triphosphate, the first and rate-limiting step in tetrahydrobiopterin (BH4) biosynthesis. The final product (BH4) is an essential co-factor for three aromatic amino acid monooxygenases (F, Y, and W). Isoform GCH-1 is the functional enzyme. GTP-CH-1 positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVEC). GTP-CH-1 deficiency is a cause of malignant hyperphenylalaninemia due to tetrahydrobiopterin deficiency. It is also responsible for defective neurotransmission due to depletion of the neurotransmitters dopamine and serotonin. GTP-CH-1 (DYT5) is a cause for dystonia 5, a DOPA-responsive dystonia, defined by sustained involuntary muscle contractions.
本文链接： http://abbiotec.immuno-online.com/view-1542340122.html
发布于 ： 2025-01-22
阅读（）
最新动态
2020-07-09
2014-12-01
2020-07-22
2020-08-02
2020-09-06
2020-09-15
2020-09-24
2016-05-31
2020-10-04
2020-10-15
联络我们
