产品名称：TLR4Antibody

产品类别：一抗

品 牌：Abbiotec

货 号：251111

规 格：0.1mg

克隆类型：

RabbitPolyclonalAntibody

亚 型：

RabbitIg

免疫原：

KLH-conjugatedsyntheticpeptideencompassingasequencewithintheC-termregionofratTLR4.

产品描述：

Toll-likereceptorfamily(TLR)hasafundamentalroleinpathogenrecognitionandactivationofinnateimmunity.TLRsarehighlyconservedfromDrosophilatohumansandsharestructuralandfunctionalsimilarities.TLRsrecognizepathogen-associatedmolecularpatterns(PAMP)thatareexpressedoninfectiousagents,andmediatetheproductionofcytokinesnecessaryforthedevelopmentofeffectiveimmunity.Toll-likereceptor4(TLR4)cooperateswithLY96andCD14tomediatetheinnateimmuneresponsetobacteriallipopolysaccharide(LPS).TLR4actsviaMYD88,TIRAPandTRAF6toleadtoNFkBactivation,cytokinesecretionandinflammatoryresponse.TLR4ishighlyexpressedinplacenta,spleenandperipheralbloodleukocytes.GeneticvariationinTLR4isassociatedwithage-relatedmaculardegeneration10(ARMD10),anirreversIBLevisionloss.

适用物种：

H,M,R,Sh,B

应用范围：

E,WB,IHC

应用说明：

E:1:500-1:1,000;WB:1:200-1:500;IHC:1:100-1:500

别 名：

Toll-likereceptor4;hToll;CD284;TLR4

形 态：

Eachvialcontains0.1mgIgGin0.1ml(1mg/ml)ofPBSpH7.4,25%glycerol,5mg/mlBSAwith0.09%sodiumazide.AntibodywaspurifiedbyProtein-Aaffinitychromatography.

保存条件：

Storeat-20°C.Minimizefreeze-thawcycles.Productisguaranteedoneyearfromthedateofshipment.

相关文献：

[1]StopigliaRetal.2015.JCancerTherapy.6:129-140.[2]KusumawardaniBetal.2013.DentalJournal,MajalahKedokteranGigi.45(3).MaternalEndotoxin-inducedFetalGrowthRestrictioninRats:FetalResponsesinToll-likeReceptor.

实验图片：