Interleukin-15 (IL-15) is a 114 amino acids cytokine that regulates T and natural killer cell activation and proliferation. Human IL-15 shares approximately 97% and 73% amino acid sequence identity with simian and mouse IL-15, respectively. IL-15 was initially isolated from the simian kidney epithelial cell line CV1/EBNA. The cytokines IL-15 and IL-2 share many biological properties and stimulatory activities (T, B, and NK cells). Both IL-15 and IL-2 stimulate mouse CTLL2 cells. In activated peripheral blood T lymphocytes, IL-2 is highly expressed but the expression of IL-15 is not detectable. There is no sequence homology between IL-15 and IL-2, though IL-15 competes for binding sites with IL-2. Both stimulate the growth of cells through the IL-2 receptor. IL-15 mRNA is expressed in many cell types and tissues including adherent peripheral blood mononuclear cells, fibroblasts, and epithelial cells, monocytes, placenta, and skeletal muscle.

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