NAC1(Nucleusaccumbens-1)isanuclearfactorthatbelongstothePOZ/BTB(Poxvirusandzincfinger/bric-a-bractramtrackbroadcomplex)domainfamily.AlsoknownasBTBD14B,itwasoriginallyidentifiedinauniqueneuronalforebrainstructureresponsIBLeforrewardmotivationandaddictivebehaviors.NAC1recruitsHDAC3andHDAC4totranscriptionallyrepressgeneexpressioninneuronalcellsandspecificallyco-repressesotherPOZ/BTBproteinsinthecentralnervoussystem.NAC1isupregulatedinseveraltumortypes,includingbreast,renalcell,andhepatocellularcarcinoma,aswellashighgradeovarianSEROuscarcinoma,whereithaslongbeensUSPectedasachemoresistancegene.ThechemoresistancemechanismreportedlyoccursthroughNAC1negativeregulationoftheGADD45pathway.NAC1hasalsobeendescribedaspartoftheextendedtranscriptionalnetworkinpluripotentcellsthatinvolvesOct-4,Sox2,Nanog,Sall1,KLF4andSall4.NAC1isoverexpressedinseveraltypesofcarcinomasincludingovarianserouscarcinomas.Expressionlevelspositivelycorrelatewithtumorrecurrenceinovarianserouscarcinomas,andintenseimmunoreactivityinprimaryovariantumorspredictsearlyrecurrence.Up-regulatedinovariancarcinomasafterchemotherapy,suggestingaroleindevelopmentofchemotherapyresistanceinovariancancer.

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