Abbiotec/NALP4 Antibody/254344/0.1 mg
商品编号:
254344
品牌:
Abbiotec LLC
市场价:
¥5840.00
美元价:
3504.00
产品分类:
单克隆抗体
公司分类:
monoclonal_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP4, also known as PYRIN-containing APAF1-like protein 4, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. In transfected 293 cells, NALP4 suppressed NF-kappaB induction by TNF-alpha and IL-1beta, suggesting NALP4 operates at a point of convergence in these two signaling pathways. NALP4 also suppressed NF-kappaB induction resulting from overexpression of several adapter proteins and protein kinases involved in these pathways, including TRAF2, TRAF6, RIP, and IRAK2, as well as the IKK-alpha and IKK-beta, suggesting that NALP4 is critical in modulating NF-kappaB activity.
品牌介绍
Abbiotec坚信与我们的科学家,客户,合作者和分销商社区建立牢固而有意义的合作伙伴关系。我们通过研究合作与社区分享我们的想法,并通过有益于生命科学界的创新和有用的产品来回馈青睐。我们欢迎有关研究或产品创意的讨论,我们将努力为此类讨论提供最有利和最机密的环境。Abbiotec利用专有技术和特殊资源开发自己的产品,以实现高质量的生产和控制。我们还从其他合作伙伴(例如个人科学家,大学外发许可部门和其他生物技术公司)获得产品和想法的许可。被许可的技术或想法被开发为商业产品,并通过我们的营销和销售网络在全球范围内销售。
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